YS 49
- Product Name
- YS 49
- CAS No.
- 132836-42-1
- Chemical Name
- YS 49
- Synonyms
- YS 49;CS-884;YS 49;YS49;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate;inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
- CBNumber
- CB41390234
- Molecular Formula
- C20H20BrNO2
- Formula Weight
- 386.2823
- MOL File
- 132836-42-1.mol
YS 49 Property
- storage temp.
- 2-8°C
- solubility
- H2O: >10mg/mL
- form
- solid
N-Bromosuccinimide Price
- Product number
- Y1521
- Product name
- YS-49 monohydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $213
- Updated
- 2022/05/15
- Product number
- Axon1685
- Product name
- YS49
- Purity
- 98%
- Packaging
- 10mg
- Price
- $148.5
- Updated
- 2021/12/16
- Product number
- 3028AH
- Product name
- 1-(Naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diolhydrobromide
- Packaging
- 1mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- CS-1002
- Product name
- YS-49
- Purity
- 95.38%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- CS-2288
- Product name
- YS-49 monohydrate
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2021/12/16
YS 49 Chemical Properties,Usage,Production
Biological Activity
YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.
in vitro
YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
Cell Viability Assay
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells) |
| Incubation Time: | 18 hours |
| Result: | Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively . |
Western Blot Analysis
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100 μΜ |
| Incubation Time: | 18 hours |
| Result: | Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
in vivo
YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>
| Animal Model: | Male Sprague Dawley rats (250-300 g) |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; 8 hours |
| Result: | Serum NOx levels were significantly reduced. |
YS 49 Preparation Products And Raw materials
Raw materials
Preparation Products
YS 49 Suppliers
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